Longevity science seems to be experiencing rapid progress, yet expected lifespan is still <100 years even if you do all the right things (diet, exercise, sleep, don't smoke, etc).
We need a lot more progress.
Here are six paths I'm excited about:
- The translation of discoveries in the last 30 years into actual medicines, such as senolytics, metformin, rapamycin, leveraging "young" blood and microbiota, etc
- Cellular rejuvenation using Yamanaka factors
- Cellular rejuvenation beyond Yamanaka factors, e.g. Sengstack et al (2022, BioRxiv)
- A better understanding of why our cells and tissues age
- Massive multi-modal 'omics and imaging data applied to aging
- Reformulating aging biology wet lab experiments as computational/AI models, e.g. language models for cellular aging
These paths each have the potential to guide us to more healthy years.