Exciting paths forward in longevity science

Longevity science seems to be experiencing rapid progress, yet expected lifespan is still <100 years even if you do all the right things (diet, exercise, sleep, don't smoke, etc).

We need a lot more progress.

Here are six paths I'm excited about:

  1. The translation of discoveries in the last 30 years into actual medicines, such as senolytics, metformin, rapamycin, leveraging "young" blood and microbiota, etc
  2. Cellular rejuvenation using Yamanaka factors
  3. Cellular rejuvenation beyond Yamanaka factors, e.g. Sengstack et al (2022, BioRxiv)
  4. A better understanding of why our cells and tissues age
  5. Massive multi-modal 'omics and imaging data applied to aging
  6. Reformulating aging biology wet lab experiments as computational/AI models, e.g. language models for cellular aging

These paths each have the potential to guide us to more healthy years.